KMID : 0387420120230010145
|
|
Korean Society of Oriental Neuropsychiatry 2012 Volume.23 No. 1 p.145 ~ p.159
|
|
The Effects of Jeoreongchajeonja-tang(Zhulingjuqianzi-tang) on the ¥âA and LPS Induced BV2 microglial cell
|
|
Ryu Chang-hee
Jung In-Chul Lee Sang-Ryong
|
|
Abstract
|
|
|
Objectives: This research investigates the effect of the JCT extract regarding Alzheimer¡¯s disease.
Methods: The effects of the JCT extract on IL-1¥â, IL-6, TNF-¥á, COX-2, NOS-II mRNA, APP mRNA, BACE mRNA, Nitric oxide(NO), and ¥âA protein production in the BV2 microglia cell lines treated with LPS and ¥âA were investigated.
Results: 1. The JCT extract suppressed the expression of IL-1¥â, IL-6, TNF-¥á, COX-2, and NOS-II mRNA in BV2 microglial cell line treated with LPS and ¥âA. 2. The JCT extract suppressed the expression of BACE and APP mRNA in BV2 microglial cell line treated with LPS and ¥âA. 3. The JCT extract suppressed the expression of Nitric oxide(NO) in BV2 microglial cell line treated with LPS and ¥âA. 4. The JCT extract suppressed the expression of ¥âA protein production in BV2 microglial cell line treated with LPS and ¥âA.
Conclusions: These results suggest that the JCT group may be effective for the treatment of Alzheimer¡¯s disease. Thus, JCT could be considered among the future therapeutic drugs indicated for the treatment of Alzheimer¡¯s disease.
|
|
KEYWORD
|
|
alzheimer¡¯s disease, Jeoreongchajeonja-tang(Zhulingjuqianzi-tang), lipopolysacchride(LPS), ¥â-amyloid(¥âA)
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|